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Water → 1-[[2-Methoxy-5-(1-methylethyl)phenyl]methyl]-4-(phenylsulfonyl)-piperazine

HRID 38292
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HRID 38292 반응식
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][C:14]=1[CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(N(CC)CC)C.O>ClCCl>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][C:14]=1[CH2:22][N:23]1[CH2:28][CH2:27][N:26]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[CH2:25][CH2:24]1
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참가 물질

6

반응물 4

HCID 962WaterHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 39064451-[[2-Methoxy-5-(1-methylethyl)phenyl]methyl]-piperazine

생성물 1

HCID 671319601-[[2-Methoxy-5-(1-methylethyl)phenyl]methyl]-4-(phenylsulfonyl)-piperazine

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

Phenylsulfonyl chloride (0.24 ml) was added to a solution of the product from step (b) (396 ml) and triethylamine (0.44 ml) in dichloromethane (3 ml) and the mixture was stirred for 3 h. Water was added and the mixture was extracted with dichloromethane. The organic extracts were dried (MgSO4), evaporated in vacuo and purified by chromatography (silica, petrol—ether as eluent) to give the sub-title compound (431 mg).

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. customevaporated in vacuo
  4. custompurified by chromatography (silica, petrol—ether as eluent)

출처 및 근거

ORD 기록
ord-9d8938016eb240ab98821a532cf6a6aa
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08524715B2

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