Hydrochloric Acid → HCID 54048152, 화합물
반응식
Cl.[C:2]1([CH2:8][C@H:9]([NH2:13])[CH2:10][O:11][CH3:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C.[Pt]=O>[CH:2]1([CH2:8][C@H:9]([NH2:13])[CH2:10][O:11][CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1참가 물질
5
실험 절차
To a solution of (S)-3-phenyl-1-methoxy-2-propylamine hydrochloride (0.5 g) in ethanol (100 ml) was added concentrated HCl (0.32 mL), and platinum oxide (0.5 g), and the reaction was shaken under hydrogen gas (4 atm) for 18 h. The reaction was filtered, concentrated, diluted with water (50 mL) and neutralized with IM NaOH (to pH≈11). The mixture was washed with chloroform (3×50 mL), and the organic extracts were washed with brine (20 mL), dried (M.SO4), filtered and concentrated to give a colorless oil (400 mg).
후처리
- filtrationThe reaction was filtered
- concentrationconcentrated
- additiondiluted with water (50 mL)
- washThe mixture was washed with chloroform (3×50 mL)
- washthe organic extracts were washed with brine (20 mL)
- customdried (M.SO4)
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-0f25ad94556d4f678e05d4c338eba960
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06310095B1
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