N-bromobutanimide → 3-Bromo-7-chloroimidazo[1,2-a]pyridine
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[CH:9][N:10]=[C:4]2[CH:3]=1.C1C(=O)N([Br:18])C(=O)C1>CN(C=O)C.CCOC(C)=O>[Br:18][C:8]1[N:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]2=[N:10][CH:9]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
7-Chloro-imidazo-[1,2-a]-pyridine (1 eq, 38.9 mmol, 5.93 g) is dissolved in DMF (20 ml) at 0° C. and NBS (1.1 eq, 42.8 mmol, 7.61 g) is added. The reaction mixture is stirred for 1 h at 0° C. and is diluted with EtOAc. The reaction mixture is washed with NaHCO3 and brine, dried over MgSO4, filtered and evaporated. The product is purified by flash column chromatography eluting with 8:2 DCM/MeOH to afford 3-bromo-7-chloro-imidazo-[1,2-a]-pyridine as a brown solid; [M+H]+=232
후처리
- washThe reaction mixture is washed with NaHCO3 and brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customThe product is purified by flash column chromatography
- washeluting with 8:2 DCM/MeOH
출처 및 근거
- ORD 기록
- ord-01a95fab00f84eef93eab8aa5a019c69
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367662B2
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