Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate → Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

HRID 383636노트

반응식

HRID 383636 반응식
[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]>N.[Ni]>[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:21]=[CH:22][C:23]([CH2:26][NH2:27])=[CH:24][CH:25]=3)=[N:14]2)[CH:7]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 59406745Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

생성물 1

HCID 59406699Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

26 mmol of ethyl{3-[6-oxo-3-(4-cyanophenyl)-6H-pyridazin-1-ylmethyl]-phenyl}carbamate are dissolved in 300 ml of methanolic ammonia solution (10%), 4 g of Raney Ni are added, and the mixture is hydrogenated at room temperature for 16 h under a hydrogen atmosphere (5 bar). The catalyst is separated off, rinsed with methanol, and the filtrate is evaporated.

후처리

  1. customThe catalyst is separated off
  2. washrinsed with methanol
  3. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-462b1582d16c4c04a98219049b4e765f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367668B2

반응 노트

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