Water → Ethyl[3-(6-oxo-3-thiocarbamoyl-6h-pyridazin-1-yl-methyl)phenyl]carbamate

HRID 383644

반응식

HRID 383644 반응식
[CH2:1]([O:3][C:4](=[O:22])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]#[N:21])=[N:14]2)[CH:7]=1)[CH3:2].[Cl-].C([NH2+]CC)C.O.[S-2:30].[Na+].[Na+].O>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:22])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20](=[S:30])[NH2:21])=[N:14]2)[CH:7]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 12618Diethylamine, hydrochlorideHCID 19906495Sodium sulfide monohydrateHCID 59406667Ethyl[3-(3-cyano-6-oxo-6H-pyridazin-1-ylmethyl)phenyl]-carbamate

생성물 1

HCID 59406698Ethyl[3-(6-oxo-3-thiocarbamoyl-6h-pyridazin-1-yl-methyl)phenyl]carbamate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
55 °C

실험 절차

200 mg (0.67 mmol) of ethyl[3-(3-cyano-6-oxo-6H-pyridazin-1-ylmethyl)-phenyl]carbamate are dissolved in 1 ml of DMF, and 219 mg (2 mmol) of diethylammonium chloride and 165 mg (2 mmol) of sodium sulfide hydrate are added. The yellow suspension is stirred at 55° C. for 2 hours. 10 ml of water are added to the reaction mixture. The precipitate is filtered off with suction, washed with water and dried in vacuo. The substance is reacted further without further purification.

후처리

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with water
  3. customdried in vacuo
  4. customThe substance is reacted further without further purification

출처 및 근거

ORD 기록
ord-31010b8f76d946b3b04a246806827eee
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367668B2

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