Acetic Acid → 7-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

HRID 383829

반응식

HRID 383829 반응식
[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[O:6][C:7]2[C:13]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:4].[CH:21]([C:23]1[N:28]=[CH:27][C:26]([C:29](=[O:31])[CH3:30])=[CH:25][CH:24]=1)=[CH2:22].C(O)(=O)C>C(O)CC.O>[C:29]([C:26]1[CH:25]=[CH:24][C:23]([CH2:21][CH2:22][N:17]2[CH2:18][CH2:19][N:14]([C:13]3[C:7]4[O:6][C:5]([C:3]([N:2]([CH3:20])[CH3:1])=[O:4])=[CH:9][C:8]=4[CH:10]=[CH:11][CH:12]=3)[CH2:15][CH2:16]2)=[N:28][CH:27]=1)(=[O:31])[CH3:30]

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 596367201-(6-Vinylpyridin-3-YL)ethanoneHCID 59636743N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide

생성물 1

HCID 596367537-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

시약·촉매·용매 2

HCID 962Water용매HCID 10311-Propanol용매

반응 조건

온도
69 °C

실험 절차

A reaction mixture of N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.078 g, 0.29 mmol) (Example 39d), 1-(6-vinylpyridin-3-yl)ethanone (0.15 g, 1.00 mmol) and acetic acid (0.016 mL, 0.29 mmol) in n-propanol (1.5 mL) and water (0.10 mL) was heated at 69° C. for 2 days. The product was purified by preparative HPLC to give the title compound. Yield: 0.046 g (38%).

후처리

  1. customThe product was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-7aeaa0ec733042b4adc410453b33167f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367676B2

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