Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 383829생성일: 2026년 10월 26일
Acetic Acid → 7-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
https://huagongshe.com/reaction/383829
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 1-(6-Vinylpyridin-3-YL)ethanone | HCID 59636720 | — |
| 반응물 | N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636743 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | 7-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide | HCID 59636753 | — |
반응 단계
A reaction mixture of N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.078 g, 0.29 mmol) (Example 39d), 1-(6-vinylpyridin-3-yl)ethanone (0.15 g, 1.00 mmol) and acetic acid (0.016 mL, 0.29 mmol) in n-propanol (1.5 mL) and water (0.10 mL) was heated at 69° C. for 2 days. The product was purified by preparative HPLC to give the title compound. Yield: 0.046 g (38%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08367676B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-7aeaa0ec733042b4adc410453b33167f |
|---|
| 출처 메모 | uspto-grants-2013_02 |
|---|
