Acetic Acid → Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone

HRID 383832

반응식

HRID 383832 반응식
[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]=[CH2:31])[N:25]=1.C(O)(=O)C>CO>[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:17][CH2:18][N:19]([CH2:31][CH2:30][C:26]5[CH:27]=[CH:28][CH:29]=[C:24]([O:23][CH3:22])[N:25]=5)[CH2:20][CH2:21]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 190915662-Methoxy-6-vinylpyridineHCID 59636763Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

생성물 1

HCID 59636730Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
120 °C

실험 절차

Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone (0.070 g, 0.25 mmol) was dissolved in methanol (1 mL). 2-Methoxy-6-vinylpyridine (0.066 g, 0.49 mmol) and acetic acid (0.014 mL, 0.25 mmol) were added. The mixture was heated by microwave irradiation to 120° C. for 10 h. The product was purified by preparative HPLC to give the title compound. Yield: 0.044 g (43%).

후처리

  1. customThe product was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-6cde1129c98247938e4fea1f5bc2e6f2
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367676B2

연결된 노트

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