Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 383832생성일: 2026년 10월 26일
Acetic Acid → Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone
https://huagongshe.com/reaction/383832
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 2-Methoxy-6-vinylpyridine | HCID 19091566 | — |
| 반응물 | Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636763 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636730 | — |
반응 단계
Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone (0.070 g, 0.25 mmol) was dissolved in methanol (1 mL). 2-Methoxy-6-vinylpyridine (0.066 g, 0.49 mmol) and acetic acid (0.014 mL, 0.25 mmol) were added. The mixture was heated by microwave irradiation to 120° C. for 10 h. The product was purified by preparative HPLC to give the title compound. Yield: 0.044 g (43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08367676B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-6cde1129c98247938e4fea1f5bc2e6f2 |
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| 출처 메모 | uspto-grants-2013_02 |
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