Water → 2-Isopropyl-3-methoxyphenol

HRID 38392노트

반응식

HRID 38392 반응식
O[C:2]([C:5]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[OH:13])([CH3:4])[CH3:3].O.C([O-])=O.[NH4+]>C(O)(=O)C.[Pd]>[CH:2]([C:5]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[OH:13])([CH3:4])[CH3:3]

참가 물질

6

반응물 3

HCID 962WaterHCID 2723923Ammonium formateHCID 595986452-(1-Hydroxy-1-methyl-ethyl)-3-methoxy-phenol

생성물 1

HCID 144655792-Isopropyl-3-methoxyphenol수율 92%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

To a solution of 2-(1-Hydroxy-1-methyl-ethyl)-3-methoxy-phenol dissolved in acetic acid (50 mL) was added 10% palladium on charcoal (500 mg), water (6 mL), and ammonium formate (7.82 g, 124 mmol). After refluxing for 1 hour, the reaction was cooled and filtered through celite. The celite pad was washed with ethyl acetate (500 mL). Water (300 mL) was added to the filtrate, and the mixture was basified (pH=8) using solid sodium bicarbonate. The ethyl acetate layer was collected and washed with water, brine, dried using anhydrous sodium sulfate and concentrated to yield 2-Isopropyl-3-methoxy-phenol (3.68 g, 92%) as pale yellow solid.

후처리

  1. temperatureAfter refluxing for 1 hour
  2. temperaturethe reaction was cooled
  3. filtrationfiltered through celite
  4. washThe celite pad was washed with ethyl acetate (500 mL)
  5. additionWater (300 mL) was added to the filtrate
  6. customThe ethyl acetate layer was collected
  7. washwashed with water, brine
  8. customdried
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-af3dfd0f129048b4a5eb8fbb5da3efbf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524725B2

반응 노트

불러오는 중…