Methanol → HCID 12821998, 화합물

HRID 383925

반응식

HRID 383925 반응식
[H-].[Na+].Cl[C:4]1[S:5][C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:7]([C:9]([O:11][CH2:12]C)=[O:10])[N:8]=1.[OH2:20].[CH3:21]O>>[CH3:21][O:20][C:4]1[S:5][C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:7]([C:9]([O:11][CH3:12])=[O:10])[N:8]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 24758Sodium hydrideHCID 59291332Ethyl 2-chloro-5-phenylthiazole-4-carboxylate

생성물 1

HCID 12821998HCID 12821998, 화합물

반응 조건

온도
70 °C

실험 절차

To a solution of 60% oily NaH in MeOH was added ethyl 2-chloro-5-phenylthiazole-4-carboxylate, followed by stirring at 70° C. for 1 hour. To the reaction mixture was added water, followed by extraction with EtOAc. The organic layer was washed with water and brine in this order, dried over MgSO4, and then concentrated under reduced pressure. The residue was purified by medium-pressure preparative liquid chromatography (silica gel, YAMAZEN YFLC WPrep2XY, CHCl3:MeOH) to obtain methyl 2-methoxy-5-phenylthiazole-4-carboxylate as a white solid.

후처리

  1. extractionfollowed by extraction with EtOAc
  2. washThe organic layer was washed with water and brine in this order
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by medium-pressure preparative liquid chromatography (silica gel, YAMAZEN YFLC WPrep2XY, CHCl3:MeOH)

출처 및 근거

ORD 기록
ord-1f0ac69bc0b4461caac4267e68d194dd
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367696B2

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