Sodium Chloride → [(E)-1-aminoethylideneamino] 6-[(5-cyanopyrazin-2-yl)amino]-4-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methylamino]pyridine-3-carboxylate

HRID 384671노트

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CCN(C(C)C)C(C)C.[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][NH:24][C:25]2[C:30]([C:31]([OH:33])=[O:32])=[CH:29][N:28]=[C:27]([NH:34][C:35]3[CH:40]=[N:39][C:38]([C:41]#[N:42])=[CH:37][N:36]=3)[CH:26]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11].CN(C(O[N:51]1N=N[C:53]2C=CC=[N:57][C:52]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.O/N=C(/N)\C.[Na+].[Cl-]>CN(C=O)C>[NH2:57]/[C:52](=[N:51]/[O:32][C:31]([C:30]1[C:25]([NH:24][CH2:23][CH:20]2[CH2:19][CH2:18][N:17]([C:15]([O:14][C:10]([CH3:13])([CH3:11])[CH3:12])=[O:16])[CH2:22][CH2:21]2)=[CH:26][C:27]([NH:34][C:35]2[CH:40]=[N:39][C:38]([C:41]#[N:42])=[CH:37][N:36]=2)=[N:28][CH:29]=1)=[O:33])/[CH3:53]

참가 물질

실험 절차

DIPEA (96 μL, 0.55 mmol) was added to a solution of 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methylamino)-6-(5-cyanopyrazin-2-ylamino)nicotinic acid (Synthesis 75-A) (50 mg, 0.11 mmol), HATU (54 mg, 0.14 mmol) in DMF (6 mL) under argon. The reaction mixture was stirred for 15 min at r.t. and (E)-N′-hydroxyacetimidamide (25 mg, 0.34 mmol) in DMF (0.5 mL) was added. The resulting solution was stirred at r.t. for 12 hr. Aqueous NaCl solution (15 mL) was added and the resulting precipitate was collected. The solid was washed with water and n-hexane to give a yellow powder (43 mg, 77%).

후처리

stirringThe resulting solution was stirred at r.t. for 12 hr
customthe resulting precipitate was collected
washThe solid was washed with water and n-hexane

출처 및 근거

ORD 기록: ord-3b5f3b6745004473a25c317baf6eb4fe
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08367658B2

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