Hydrogen Bromide → (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

반응식

C(OC([NH:11][C@@H:12]([CH2:17][C:18]([F:27])([F:26])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14])=O)C1C=CC=CC=1.[BrH:28]>>[BrH:28].[NH2:11][C@@H:12]([CH2:17][C:18]([F:26])([F:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14]

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 57535357Methyl (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenylpentanoate

생성물 1

HCID 66939992(S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

실험 절차

A mixture of (S)-methyl 2-(benzyloxycarbonylamino)-4,4-difluoro-5-phenylpentanoate (188 mg, 0.5 mmol) and hydrogen bromide (2 mL) was stirred at RT for two hr, after which the solvent was removed to give the title (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide.

후처리

customafter which the solvent was removed

출처 및 근거

ORD 기록: ord-c951b990760a4f349cdf94b6235ce274
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08367732B2

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