Hydrochloric Acid → 5-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide dihydrochloride

HRID 38475노트

반응식

HRID 38475 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([CH2:22][C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:24]4[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=4)[C:29]([NH2:31])=[O:30])[CH:19]=3)[O:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33]>O1CCOCC1>[ClH:33].[ClH:33].[O:23]=[C:21]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:24]3[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=3)[C:29]([NH2:31])=[O:30])[CH:19]=2)[O:14][C:11]2([CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:22]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 579310025-{1'-tert-Butoxycarbonyl-4-oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide

생성물 1

HCID 667820395-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide (1.30 g) was suspended in dioxane (10 ml) and 4N HCl in dioxane (20 ml) was added thereto, and stirred at room temperature for 18 h. The resulted precipitate was filtered, washed with dioxane and Et2O to obtain the intended compound as a colorless solid.

후처리

  1. filtrationThe resulted precipitate was filtered
  2. washwashed with dioxane and Et2O

출처 및 근거

ORD 기록
ord-1fa9396ccade412b86164f9adbce59fa
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524730B2

반응 노트

불러오는 중…