Methanol → 6-Iodoquinazolin-4-one

HRID 384754

반응식

HRID 384754 반응식
[I:1][C:2]1[CH:10]=[C:6]([C:7](O)=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.C([O-])([O-])OC.C([O-])(=O)C.[NH4+:21].[CH3:22]O>O>[I:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:22][NH:21][C:7]2=[O:8]

참가 물질

6

반응물 4

HCID 887MethanolHCID 72911Benzoic acid, 2-amino-5-iodo-HCID 517165Ammonium AcetateHCID 53629101Methylorthoformate

생성물 1

HCID 1354016666-Iodoquinazolin-4-one수율 93%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 10-mL volume stainless steel pressure-resistant vessel were placed 1.0 g (3.8 mmol) of 5-iodoanthranilic acid, 0.81 g (7.6 mmol) of methyl orthoformate, 0.59 g (7.6 mmol) of ammonium acetate, and 4.0 mL of methanol. The reaction was carried out at 120° C. for 3 hours. After the reaction was complete, the reaction mixture was cooled to room temperature, and 40 mL of water was added to the reaction mixture. The resulting aqueous mixture was stirred for 15 minutes and filtered to give 0.97 g (isolated yield: 93%) of 6-iodoquinazolin-4-one as a pale gray crystalline product.

후처리

  1. customIn a 10-mL volume stainless steel pressure-resistant vessel were placed
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-e0cee7944b3d4854b339820c84655ba9
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367824B2

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