Hydrochloric Acid → 6-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

HRID 38479

반응식

HRID 38479 반응식
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[C:12]3[C:29](=[CH:30][CH:31]=2)[O:28][C:15]2([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][C:13]3=[O:32])=[N:8][CH:9]=1)(=[O:3])[NH2:2].[ClH:33].CCOCC>O1CCOCC1>[ClH:33].[ClH:33].[O:32]=[C:13]1[C:12]2[C:29](=[CH:30][CH:31]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([C:1]([NH2:2])=[O:3])=[CH:9][N:8]=3)[CH:11]=2)[O:28][C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58208682tert-Butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

생성물 1

HCID 667818846-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.

후처리

  1. customthe resulted precipitate was collected by aeration
  2. washwashed with Et2O
  3. customto give

출처 및 근거

ORD 기록
ord-6add63eca05c4a7ea8bd746aa231ffd3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524730B2

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