Hydroxyamine hydrochloride → 4-methoxy-2,3-dihydro-1H-inden-1-one oxime

HRID 384973

반응식

HRID 384973 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=O.[NH2:13][OH:14].Cl.C([O-])(=O)C.[Na+]>CO>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=[N:13][OH:14]

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 45474914-methoxy-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 766564544-methoxy-2,3-dihydro-1H-inden-1-one oxime수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-methoxy-2,3-dihydro-1H-inden-1-one (1.0 g, 1.0 eq.) in 25 ml MeOH was added NH2OH.HCl (0.493 g, 1.15 eq.) and sodium acetate (0.597 g, 1.18 eq.). The resulting mixture was stirred at room temperature overnight. The reaction mixture was diluted with 100 ml ice-water. The white precipitate was collected by filtration, washed with 3×20 ml water and dried in vacuo to afford 1.08 g (yield 99%) 4-methoxy-2,3-dihydro-1H-inden-1-one oxime which was used to next step without further purification.

후처리

  1. filtrationThe white precipitate was collected by filtration
  2. washwashed with 3×20 ml water
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-d3a87c1c72994cb09db54a91dd7ee20b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367836B2

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