Water → Methyl 3-t-butyl-4-methoxy-5-methylsulfanylbenzoate

HRID 385102노트

반응식

HRID 385102 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([S:16][CH3:17])[C:14]=1[OH:15])[C:8]([O:10][CH3:11])=[O:9])([CH3:4])([CH3:3])[CH3:2].[C:18](=O)([O-])[O-].[K+].[K+].COS(=O)(=O)OC.O>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([S:16][CH3:17])[C:14]=1[O:15][CH3:18])[C:8]([O:10][CH3:11])=[O:9])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 86668170Methyl 3-t-butyl-4-hydroxy-5-methylsulfanylbenzoate

생성물 1

HCID 68108649Methyl 3-t-butyl-4-methoxy-5-methylsulfanylbenzoate수율 86.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl 3-t-butyl-4-hydroxy-5-methylsulfanylbenzoate (377 mg) was dissolved in N,N-dimethylformamide (7 mL), and potassium carbonate (818 mg) and dimethylsulfuric acid (0.32 mL) were added to the solution, and then the mixture was stirred at room temperature for 20 hours. Water was added to the reaction solution, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (344 mg) as a pale yellow oily substance.

후처리

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-cc17653a6d7e4ec2919e587a92ef8b37
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367843B2

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