Lithium hydroxide, monohydrate → 3-Cyano-4-methoxybenzoic acid
반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].O.[OH-].[Li+]>O1CCCC1.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]참가 물질
5
실험 절차
Methyl 3-cyano-4-methoxybenzoate (879 mg) was dissolved in tetrahydrofuran (8 mL) and water (4 mL), and lithium hydroxide monohydrate (772 mg) was added to the solution, and then the mixture was stirred at mom temperature for 1 hour. The organic solvent was distilled off under reduced pressure and acidified with 2N hydrochloric acid, and then the precipitated crystal was collected by filtration to obtain the title compound (754 mg) as a colorless crystal.
후처리
- distillationThe organic solvent was distilled off under reduced pressure
- filtrationthe precipitated crystal was collected by filtration
출처 및 근거
- ORD 기록
- ord-afce05d383564db4869144b7ab6bb707
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367843B2
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