Lithium hydroxide, monohydrate → 3-Cyano-4-methoxybenzoic acid

HRID 385133

반응식

HRID 385133 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].O.[OH-].[Li+]>O1CCCC1.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 2801011Methyl 3-cyano-4-methoxybenzoate

생성물 1

HCID 219909723-Cyano-4-methoxybenzoic acid수율 92.6%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 3-cyano-4-methoxybenzoate (879 mg) was dissolved in tetrahydrofuran (8 mL) and water (4 mL), and lithium hydroxide monohydrate (772 mg) was added to the solution, and then the mixture was stirred at mom temperature for 1 hour. The organic solvent was distilled off under reduced pressure and acidified with 2N hydrochloric acid, and then the precipitated crystal was collected by filtration to obtain the title compound (754 mg) as a colorless crystal.

후처리

  1. distillationThe organic solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystal was collected by filtration

출처 및 근거

ORD 기록
ord-afce05d383564db4869144b7ab6bb707
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367843B2

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