3-[(2-Dimethylamino-4-nitro-benzoyl)-amino]-2-amino-6-methoxy-pyridine → 2-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

HRID 3852노트

반응식

HRID 3852 반응식
[CH3:1][N:2]([CH3:24])[C:3]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:4]=1[C:5]([NH:7][C:8]1[C:9]([NH2:16])=[N:10][C:11]([O:14][CH3:15])=[CH:12][CH:13]=1)=O>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]([CH3:24])[C:3]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:4]=1[C:5]1[NH:7][C:8]2[C:9]([N:16]=1)=[N:10][C:11]([O:14][CH3:15])=[CH:12][CH:13]=2

참가 물질

3

반응물 1

HCID 135324023-[(2-Dimethylamino-4-nitro-benzoyl)-amino]-2-amino-6-methoxy-pyridine

생성물 1

HCID 135323492-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

A suspension of 1.4 gm of 3-[(2-dimethylamino-4-nitro-benzoyl)-amino]-2-amino-6-methoxy-pyridine in 40 ml of phosphorus oxychloride is refluxed for three hours. The phosphorus oxychloride is evaporated off by about two-thirds, and the residue is poured into water. The solution obtained is made ammoniacal, and the product precipitated is purified over a silica gel column [eluant: methylene chloride/ethanol (100:0 to 100:0.5)].

후처리

  1. temperatureis refluxed for three hours
  2. customThe phosphorus oxychloride is evaporated off by about two-thirds
  3. additionthe residue is poured into water
  4. customThe solution obtained
  5. customthe product precipitated
  6. customis purified over a silica gel column [eluant: methylene chloride/ethanol (100:0 to 100:0.5)]

출처 및 근거

ORD 기록
ord-072da412b7c74d68ae2b0cbe80cf9367
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722929

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