2,3-Diamino-6-methoxypyridine dihydrochloride → 2-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

HRID 3853노트

반응식

HRID 3853 반응식
[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.Cl.Cl.[NH2:18][C:19]1[C:24]([NH2:25])=[CH:23][CH:22]=[C:21]([O:26][CH3:27])[N:20]=1>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:25][C:24]2[C:19]([N:18]=1)=[N:20][C:21]([O:26][CH3:27])=[CH:22][CH:23]=2

참가 물질

4

반응물 2

HCID 30239192,3-Diamino-6-methoxypyridine dihydrochlorideHCID 201382202-(Dimethylamino)-4-nitrobenzoic acid

생성물 1

HCID 135323492-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

An amount of 0.45 gm of 2-dimethylamino-4-nitro-benzoic acid is suspended in 15 ml of phosphorus oxychloride, and 0.45 gm of 2,3-diamino-6-methoxy-pyridine dihydrochloride are added. The mixture is refluxed for two hours and after cooling poured onto water. The aqueous solution is made ammoniacal with cooling, and the product precipitated is treated as in Example 4(b).

후처리

  1. temperatureThe mixture is refluxed for two hours
  2. temperatureafter cooling
  3. additionpoured onto water
  4. temperaturewith cooling
  5. customthe product precipitated
  6. additionis treated as in Example 4(b)

출처 및 근거

ORD 기록
ord-2a7e3c04034f4962805f2b8605f567fe
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722929

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