Hydrochloric Acid → [2-Fluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

HRID 385705노트

반응식

HRID 385705 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:15])([CH3:14])[CH3:13])[CH:5]=[CH:6][C:7]=1[CH:8]=[CH:9][O:10]C.Cl>CC(C)=O.O.C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([C:12]([OH:15])([CH3:14])[CH3:13])[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]=[O:10]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 671174472-{3-Fluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol

생성물 1

HCID 58216657[2-Fluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

시약·촉매·용매 3

HCID 180Acetone용매HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

To a room temperature solution of 2-{3-fluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (100 mg, 0.48 mmol) in acetone (5 mL) was added dropwise 4 M aqueous hydrochloric acid (5 mL, 20 mmol). The reaction was stirred at room temperature for two hours. The mixture was then diluted with 25 mL of water and 50 mL of diethyl ether. The water phase was extracted with diethyl ether (2×) and the combined organic layers were washed with saturated aqueous sodium bicarbonate and brine, dried and concentrated in vacuo to afford the title compound.

후처리

  1. extractionThe water phase was extracted with diethyl ether (2×)
  2. washthe combined organic layers were washed with saturated aqueous sodium bicarbonate and brine
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7039acb10c7b48e4a9b5ebf19bbb03b0
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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