5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

HRID 385715노트

반응식

HRID 385715 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([N+:16]([O-])=O)=[C:13]([C:19]([NH2:21])=[O:20])[CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>CO.[Pt]>[NH2:16][C:14]1[S:15][C:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:10][CH:9]=2)=[CH:12][C:13]=1[C:19]([NH2:21])=[O:20]

참가 물질

4

반응물 1

HCID 595257655-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide

생성물 1

HCID 582564812-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 887Methanol용매

실험 절차

Nitro reduction, Method A: 5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide (0.96 g, 2.94 mmol) and Pt/C, doped with V (0.191 g, 0.029 mmol) were stirred in MeOH (60 mL) at room temperature under a balloon of H2 for 90 minutes. The catalyst was removed by filtering through Celite, which was subsequently washed with DMF. The solvent was removed in vacuo and the residue triturated in EtOH to give the title compound as a dark brown solid.

후처리

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite, which
  3. washwas subsequently washed with DMF
  4. customThe solvent was removed in vacuo
  5. customthe residue triturated in EtOH

출처 및 근거

ORD 기록
ord-6d60e84ed0044eb395e6fdf29b43a93b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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