Water → 5-[4-(1-Hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide

HRID 385726노트

반응식

HRID 385726 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([N+:15]([O-:17])=[O:16])=[C:12]([C:18]([NH2:20])=[O:19])[CH:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+].O>CO>[OH:3][CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([N+:15]([O-:17])=[O:16])=[C:12]([C:18]([NH2:20])=[O:19])[CH:11]=2)=[CH:6][CH:5]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 595260295-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide

생성물 1

HCID 595257315-[4-(1-Hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide (0.21 g, 0.723 mmol) was taken up in MeOH (4 mL), followed by the addition of sodium borohydride (0.027 g, 0.723 mmol). The reaction mixture stirred at room temperature for 3 hours. Water was added and the products extracted into EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a yellow solid.

후처리

  1. extractionthe products extracted into EtOAc (2×)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f70ad1fd60414e27a90a0ab4d63d3b9d
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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