Hydrazine hydrate (1:1) → HCID 178526552, 화합물

HRID 385742노트

반응식

HRID 385742 반응식
C[N:2](/[CH:4]=[N:5]/[C:6]([C:8]1[S:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=1)=O)C.O.[NH2:17]N>CC(O)=O>[N+:13]([C:10]1[S:9][C:8]([C:6]2[N:5]=[CH:4][NH:2][N:17]=2)=[CH:12][CH:11]=1)([O-:15])=[O:14]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 178484334HCID 178484334, 화합물

생성물 1

HCID 178526552HCID 178526552, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
90 °C

실험 절차

N-[(1E)-(Dimethylamino)methylene]-5-nitrothiophene-2-carboxamide (7.00 g, 30.8 mmol) was combined with AcOH (70 mL) and hydrazine hydrate (65% wt, 2.76 mL, 37.0 mmol) and stirred at 90° C. for 1.5 h. The yellow solution was cooled to room temperature and concentrated. The resulting slurry was diluted with CH2Cl2 and saturated NaHCO3 and stirred. The yellow precipitate was isolated by filtration and dried to provide the title compound as a yellow solid.

후처리

  1. temperatureThe yellow solution was cooled to room temperature
  2. concentrationconcentrated
  3. additionThe resulting slurry was diluted with CH2Cl2 and saturated NaHCO3
  4. stirringstirred
  5. customThe yellow precipitate was isolated by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-b36b9329cb3545db8ca49daa2f1197f4
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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