Hydrazinecarboxaldehyde → 5-(4-Bromophenyl)-1H-1,2,4-triazole

HRID 385751

반응식

HRID 385751 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:12])OCC)=[CH:4][CH:3]=1.[NH2:13][NH:14][CH:15]=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[CH:15][NH:14][N:13]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 12229HydrazinecarboxaldehydeHCID 10466301Ethyl 4-bromobenzene-1-carboximidate

생성물 1

HCID 469487345-(4-Bromophenyl)-1H-1,2,4-triazole

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Into a 1000 mL 3-necked flask, was placed a solution of ethyl 4-bromobenzenecarboximidoate (54.0 g, 237 mmol) in xylene (500 mL) To the mixture was added NH2NHCHO (14.22 g, 237 mmol). The resulting solution was heated to reflux overnight. The reaction mixture was cooled in an ice bath and filtered. The solid was washed with 700 mL of petroleum ether and dried in an oven under reduced pressure to afford 3-(4-bromophenyl)-1H-1,2,4-triazole (crude) as a white solid.

후처리

  1. customInto a 1000 mL 3-necked flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight
  4. temperatureThe reaction mixture was cooled in an ice bath
  5. filtrationfiltered
  6. washThe solid was washed with 700 mL of petroleum ether
  7. customdried in an oven under reduced pressure

출처 및 근거

ORD 기록
ord-a6dfce0089d44b1f9ed693d88e2046e9
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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