Sodium borohydride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 385756노트

반응식

HRID 385756 반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO.ClCCl.O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 2

HCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

생성물 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanol

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

A solution of 1-(6-bromopyridin-2-yl)ethanone (2.9636 g, 14.82 mmol) in methanol (40 mL) at 0° C. was charged with sodium borohydride (1.682 g, 44.4 mmol) and then allowed to warm to room temperature. After 2.5 hours, the reaction mixture was diluted with dichloromethane (60 mL) and water (60 mL) and the layers were separated. The organic layer was dried over sodium sulfate, filtered, and concentrated to yield the title compound.

후처리

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7d668943413840dabfbdd461a0cf7016
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

반응 노트

불러오는 중…