Formic Acid → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

HRID 385797노트

반응식

HRID 385797 반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:16])[CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].C(O)=O>CO.C(OCC)(=O)C.C(=O)(O)[O-].[Na+].O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:16])[CH2:9][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[CH:5]=[CH:4][CH:3]=1

참가 물질

8

반응물 3

HCID 284Formic AcidHCID 4311764Sodium borohydrideHCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

생성물 1

HCID 595260601-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

시약·촉매·용매 4

HCID 887Methanol용매HCID 962Water용매HCID 8857Ethyl Acetate용매HCID 516892Sodium Bicarbonate용매

실험 절차

To a solution of 1-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanone (234 mg, 0.82 mmol) in methanol at 0° C. was added sodium borohydride (31.0 mg, 0.82 mmol). After 30 minutes, formic acid (0.1 mL) was added and then the reaction mixture was diluted with ethyl acetate (40 mL), saturated aqueous sodium bicarbonate (10 mL), and water (10 mL). The layers were separated and the organic layer was washed with brine (10 mL), dried over sodium sulfate, filtered, and concentrated to give the title compound.

후처리

  1. customThe layers were separated
  2. washthe organic layer was washed with brine (10 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c55cd15ae1fc47f487154705eca98c17
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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