(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → 6-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

HRID 38585

반응식

HRID 38585 반응식
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][NH:20][CH2:21][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2].Cl.[CH3:23][N:24]([CH3:31])[CH2:25]/[CH:26]=[CH:27]/[C:28](O)=[O:29]>>[CH3:23][N:24]([CH3:31])[CH2:25]/[CH:26]=[CH:27]/[C:28]([N:20]1[CH2:21][C:17]2[S:16][C:12]3[N:13]=[CH:14][N:15]=[C:10]([NH:9][C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[CH:2])[CH:4]=4)[C:11]=3[C:18]=2[CH2:19]1)=[O:29]

참가 물질

3

반응물 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 58116839N-(3-Ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

생성물 1

HCID 581167906-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

실험 절차

In analogy to Example 89, the title compound was prepared from N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 27A (40 mg, 0.12 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (27 mg, 0.17 mmol) to yield 11 mg (22%).

후처리

  1. customto yield 11 mg (22%)

출처 및 근거

ORD 기록
ord-1469af8260444a3382513b1787b0d9cf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524722B2

연결된 노트

불러오는 중…