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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 38585생성일: 2026년 10월 25일

(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → 6-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

https://huagongshe.com/reaction/38585

반응식

참여 물질

역할이름HCID투입량
반응물(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 45358758—
반응물N-(3-Ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amineHCID 58116839—
생성물6-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amineHCID 58116790—

반응 단계

In analogy to Example 89, the title compound was prepared from N-(3-ethynylphenyl)-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 27A (40 mg, 0.12 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (27 mg, 0.17 mmol) to yield 11 mg (22%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08524722B2
출처 데이터셋uspto-grants-2013_09
ORD IDord-1469af8260444a3382513b1787b0d9cf
출처 메모uspto-grants-2013_09