Methanol → 2-(6-Bromopyridin-2-yl)acetic acid
반응식
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]#N)[CH:5]=[CH:4][CH:3]=1.[OH-:11].[Na+].C[OH:14]>C(OCC)(=O)C.O>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([OH:14])=[O:11])[CH:5]=[CH:4][CH:3]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
(6-Bromopyridin-2-yl)acetonitrile (50 mg, 0.25 mmol) was taken up in methanol (2 mL) and 1 N aqueous sodium hydroxide (2 ml, 2 mmol) was added. The reaction was heated to 80° C. overnight. Upon completion, the reaction was cooled to ambient temperature, diluted with ethyl acetate (15 mL) and water (15 mL), and the layers were separated. The aqueous layer was acidified with 2N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to afford the title compound which was used without further purification.
후처리
- temperatureUpon completion, the reaction was cooled to ambient temperature
- customthe layers were separated
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-aeefa89cac284b3c991110c380b5d1c7
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367706B2
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