Methanol → 2-(6-Bromopyridin-2-yl)acetic acid

HRID 385855

반응식

HRID 385855 반응식
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]#N)[CH:5]=[CH:4][CH:3]=1.[OH-:11].[Na+].C[OH:14]>C(OCC)(=O)C.O>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([OH:14])=[O:11])[CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 6428642-(6-Bromopyridin-2-yl)acetonitrile

생성물 1

HCID 468357142-(6-Bromopyridin-2-yl)acetic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

(6-Bromopyridin-2-yl)acetonitrile (50 mg, 0.25 mmol) was taken up in methanol (2 mL) and 1 N aqueous sodium hydroxide (2 ml, 2 mmol) was added. The reaction was heated to 80° C. overnight. Upon completion, the reaction was cooled to ambient temperature, diluted with ethyl acetate (15 mL) and water (15 mL), and the layers were separated. The aqueous layer was acidified with 2N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to afford the title compound which was used without further purification.

후처리

  1. temperatureUpon completion, the reaction was cooled to ambient temperature
  2. customthe layers were separated
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-aeefa89cac284b3c991110c380b5d1c7
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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