Water → 2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol

HRID 385887

반응식

HRID 385887 반응식
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][OH:8])[CH:3]=[N:2]1.[OH-].[K+].[CH3:11]I.O>C(O)C>[CH3:11][N:1]1[CH:5]=[C:4]([CH2:6][CH2:7][OH:8])[CH:3]=[N:2]1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 42936042-(1H-Pyrazol-4-yl)ethanol

생성물 1

HCID 170280762-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution cooled (0° C.) of 2-(1H-pyrazol-4-yl)ethanol (93 g, 0.83 mol) and potassium hydroxide (48.8 g, 0.87 mol) in absolute ethanol (9.25 L) was added methyl iodide (178 g, 1.25 mol) dropwise. The mixture was allowed to react for 30 min, at which time it was poured into water (400 mL) and extracted with diethyl ether (4×100 mL). The combined organic layers were dried (Na2SO4), filtered, concentrated in vacuo, and purified by vacuum distillation to afford the title compound.

후처리

  1. customto react for 30 min, at which time it
  2. extractionextracted with diethyl ether (4×100 mL)
  3. dry with materialThe combined organic layers were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. distillationpurified by vacuum distillation

출처 및 근거

ORD 기록
ord-925e031597ef44eda47f838e3ea4011f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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