2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 385911

반응식

HRID 385911 반응식
Br[C:2]1[N:7]=[C:6]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[S:15][C:16]([C:22]2[C:27]([F:28])=[CH:26][C:25]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:24][C:23]=2[F:33])=[CH:17][C:18]=1[C:19]([NH2:21])=[O:20]>>[C:11]([C:8]1([C:6]2[N:7]=[C:2]([NH:13][C:14]3[S:15][C:16]([C:22]4[C:23]([F:33])=[CH:24][C:25]([C:29]([OH:32])([CH3:30])[CH3:31])=[CH:26][C:27]=4[F:28])=[CH:17][C:18]=3[C:19]([NH2:21])=[O:20])[CH:3]=[CH:4][CH:5]=2)[CH2:10][CH2:9]1)#[N:12]

참가 물질

3

반응물 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256751-(6-Bromopyridin-2-YL)cyclopropanecarbonitrile

생성물 1

HCID 595255722-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

실험 절차

The title compound was prepared according to the procedure described in Example 1 using 1-(6-bromopyridin-2-yl)cyclopropanecarbonitrile (107 mg, 0.48 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) as starting materials.

출처 및 근거

ORD 기록
ord-ab4cfb6f6dd84022ae903b9934098b2c
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

연결된 노트

불러오는 중…