Hydrogen Peroxide → 2-(6-Bromopyridin-2-yl)-2-methylpropanamide
반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH:5]=[CH:4][CH:3]=1.OO.C(=O)([O-])[O-:16].[K+].[K+]>CS(C)=O>[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:16])[CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 2-(6-bromopyridin-2-yl)-2-methylpropanenitrile (Example 367, Step 1) (200 mg, 0.89 mmol) in dimethylsulfoxide (4 mL) was added hydrogen peroxide (0.42 mL, 4.8 mmol) and potassium carbonate (1.23 g, 8.89 mmol). The reaction was then stirred overnight at 70° C. The resulting slurry was cooled to ambient temperature, filtered and directly purified by reverse phase HPLC (10-100% acteonitrile/water+0.05% TFA modifier) to yield the title compound.
후처리
- temperatureThe resulting slurry was cooled to ambient temperature
- filtrationfiltered
- customdirectly purified by reverse phase HPLC (10-100% acteonitrile/water+0.05% TFA modifier)
출처 및 근거
- ORD 기록
- ord-78b45d5989f648298460c2852aeefe9f
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367706B2
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