Sodium borohydride → (6-Chloro-2-methylpyridin-3-yl)methanol

HRID 385945노트

반응식

HRID 385945 반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[C:6]([CH3:12])[N:5]=1>CO>[Cl:3][C:4]1[N:5]=[C:6]([CH3:12])[C:7]([CH2:8][OH:9])=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 447548676-Chloro-2-methylpyridine-3-carbaldehyde

생성물 1

HCID 59525984(6-Chloro-2-methylpyridin-3-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (0.73 g, 19.28 mmol) was added to a solution of 6-chloro-2-methylnicotinaldehyde (1.5 g, 9.64 mmol) in methanol (38.6 mL) at room temperature. The mixture was stirred for 2 hours, then quenched with water and saturated aqueous sodium bicarbonate, and extracted three times with ethyl acetate. The organic layers were combined, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound.

후처리

  1. customquenched with water and saturated aqueous sodium bicarbonate
  2. extractionextracted three times with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-793b09812c5f4bde9dc40ab0690a36f3
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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