Morpholine → Ammonia

HRID 385947

반응식

HRID 385947 반응식
Br[CH2:2][C:3]1[C:4]([CH3:10])=[N:5][C:6]([Cl:9])=[CH:7][CH:8]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.CCN(C(C)C)C(C)C>C(Cl)Cl.O>[NH3:5].[Cl:9][C:6]1[N:5]=[C:4]([CH3:10])[C:3]([CH2:2][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1

참가 물질

7

반응물 3

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 595261743-(Bromomethyl)-6-chloro-2-methylpyridine

생성물 2

HCID 222AmmoniaHCID 513419534-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

3-(Bromomethyl)-6-chloro-2-methylpyridine (500 mg, 2.27 mmol) was taken up in CH2Cl2 (5.0 mL) and morpholine (257 μL, 2.95 mmol) and DIEA (594 μL, 3.40 mmol) were added. After stirring at room temperature overnight, the reaction was diluted with water and extracted with CH2Cl2 (2×). The combined organic layers were dried over MgSO4, filtered, and evaporated. Flash chromatography (0-10% MeOH (w/2 M NH3)/CH2Cl2) provided the title compound as a colorless oil.

후처리

  1. extractionextracted with CH2Cl2 (2×)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-d3b4e8cd363f4bcba022ccba1d4517a5
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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