Triethylamine → 4-Ethoxy-2-pyrrolidin-1-ylpyrimidine

HRID 386096노트

반응식

HRID 386096 반응식
Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.CCN(CC)CC>C1COCC1>[CH2:9]([O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:7]=1)[CH3:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 47372802-Chloro-4-ethoxypyrimidine

생성물 1

HCID 595258964-Ethoxy-2-pyrrolidin-1-ylpyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-chloro-4-ethoxypyrimidine (3 g, 19 mol) in THF (410 mL) was added pyrrolidine (2.7 g, 38 mmol) and Et3N (5.8 g, 57 mmol) and the reaction mixture was heated to reflux overnight. The solvent was evaporated and the residue was partioned between water and EtOAc. The aqueous phase was extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered, and concentrated to give the title compound.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux overnight
  3. customThe solvent was evaporated
  4. extractionThe aqueous phase was extracted with EtOAc
  5. dry with materialThe combined organic phases were dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7a911ec2b8604f458f43e5d3f63a6713
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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