반응식
CC1SC=CC=1.BrBr.[Br:9][C:10]1[CH:14]=[C:13](Br)[S:12][C:11]=1[CH3:16].CC1(C)C(C)(C)OB([CH2:25][O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)O1.C(OB1OC(C)(C)C(C)(C)O1)(C)C.BrC1C=CC(OC)=CC=1>>[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:13]2[S:12][C:11]([CH3:16])=[C:10]([Br:9])[CH:14]=2)=[CH:29][CH:28]=1참가 물질
실험 절차
The synthesis starts from commercially available 2-methylthiophene, which is brominated in the 3 and 5 position with bromine. The 3,5-dibromo-2-methylthiophene reacts in a Suzuki coupling with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl) methoxybenzene, made from 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and 4-bromoanisole in a grignard reaction to obtain 5-(4′-methoxyphenyl)-3-bromo-2-methylthiophene. This compound is reacts with butyl lithium and octafluorocyclopentene to obtain the reaction product. Another example synthesizes 1,2-bis(2-methyl-5-phenyl-3-thienyl) perfluorocyclopentene, while 1,2-bis(5′-(4″-hydroxyphenyl)-2′-methylthien-3′-yl) perfluorocyclopentene is obtained from 1,2-bis(5′(4″methoxyphenyl)-2′-methylthien-3′-yl) perfluorocyclopentene via reaction with BBr3.
출처 및 근거
- ORD 기록
- ord-ca8f2daa858a441881bd6c75adb53477
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08368999B2
연결된 노트
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