Hydrazine hydrate (1:1) → ethyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate

HRID 386342

반응식

HRID 386342 반응식
[C:1]([CH:4]([C:11](=O)[CH3:12])[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=O)[CH3:2].O.[NH2:15][NH2:16]>C(O)C>[CH3:2][C:1]1[C:4]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:11]([CH3:12])[NH:16][N:15]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 87820Ethyl 3-acetyl-4-oxopentanoate

생성물 1

HCID 16394806ethyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate수율 72%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of ethyl 3-acetyl-4-oxopentanoate (synthesized as described D. P. Shrout and D. A. Lightner, Synth. Commun. 20 (1990), 2075) (9.676 g, 51.96 mmol) in ethanol, at 0° C., was added slowly a solution of hydrazine hydrate (2.990 g, 59.75 g) in absolute ethanol. The reaction mixture was warmed to room temperature and stirred for 2 hours. After removing ethanol under vacuum, dichloromethane and water were added to the crude product and the organic layer was separated. The aqueous layer was extracted further with dichloromethane and the combined organic extracts were washed with water. After drying over MgSO4 and evaporation of the solvent under reduced pressure, the pyrazole was isolated as a yellow oil. Yield: 72% (6.777 g, 37.2 mmol).

후처리

  1. customAfter removing ethanol under vacuum, dichloromethane and water
  2. additionwere added to the crude product
  3. customthe organic layer was separated
  4. extractionThe aqueous layer was extracted further with dichloromethane
  5. washthe combined organic extracts were washed with water
  6. dry with materialAfter drying over MgSO4 and evaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-9c886412d52e4145be71feddcd8fb175
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372379B2

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