1-Trityl-4-ethoxymethylpyrazole → 4-Ethoxymethylpyrazole

HRID 386346

반응식

HRID 386346 반응식
C([N:20]1[CH:24]=[C:23]([CH2:25][O:26][CH2:27][CH3:28])[CH:22]=[N:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)C.CC(C)=O.Cl>[CH2:27]([O:26][CH2:25][C:23]1[CH:24]=[N:20][NH:21][CH:22]=1)[CH3:28]

참가 물질

4

반응물 1

HCID 685285131-Trityl-4-ethoxymethylpyrazole

생성물 1

HCID 685328294-Ethoxymethylpyrazole수율 44%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 21889777Acetone ethanol용매

반응 조건

온도
80 °C

실험 절차

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

후처리

  1. additionwas added to the resulting solution
  2. temperatureAfter cooling to room temperature
  3. filtrationthe reaction mixture was filtered
  4. washwashed with dichloromethane
  5. extractionextracted with dichloromethane
  6. dry with materialdried over MgSO4
  7. customthe solvent was evaporated under vacuum

출처 및 근거

ORD 기록
ord-0bea6f2677724088b732e77957c79f23
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372379B2

연결된 노트

불러오는 중…