Methyl iodide → Methyl 3-(benzyloxy)-5-methoxybenzoate

HRID 38655노트

반응식

HRID 38655 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([OH:19])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 7472028Methyl 3-(benzyloxy)-5-hydroxybenzoate

생성물 1

HCID 12658782Methyl 3-(benzyloxy)-5-methoxybenzoate수율 85%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of 4.0 g (0.0165 mmol) methyl 3-(benzyloxy)-5-hydroxybenzoate (160), 6.84 g (0.0495 mmol) potassium carbonate, and 11.71 g (0.0825 mmol) iodomethane in the 200 mL of acetone was stirred at room temperature for 24 h. After the mixture was filtered and evaporated, the residue was washed with water. The methyl 3-(benzyloxy)-5-methoxybenzoate (161) was obtained as a white solid.

후처리

  1. filtrationAfter the mixture was filtered
  2. customevaporated
  3. washthe residue was washed with water

출처 및 근거

ORD 기록
ord-34cdac811085477c8b89e990af9512d2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524740B2

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