Sodium Hydroxide → 3-(Benzyloxy)-5-methoxybenzoic acid

HRID 38656노트

반응식

HRID 38656 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([O:14]C)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 12658782Methyl 3-(benzyloxy)-5-methoxybenzoate

생성물 1

HCID 126587813-(Benzyloxy)-5-methoxybenzoic acid수율 90%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

4.45 g (0.0174 mmol) of methyl 3-(benzyloxy)-5-methoxybenzoate (161) was suspended in 120 mL of 95% ethanol and 5 mL water. An amount of 2.00 g (0.05 mmol) of sodium hydroxide was added. The mixture was heated at reflux for 1 h. After the mixture was evaporated, the residue was quenched with 150 mL of water. The solution was neutralized with dil aq HCl and then the precipitate was collected and washed with water and acetone to give 162.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 1 h
  3. customAfter the mixture was evaporated
  4. customthe residue was quenched with 150 mL of water
  5. customthe precipitate was collected
  6. washwashed with water and acetone

출처 및 근거

ORD 기록
ord-b7cce4cbf9a24832b82a74bb5d1139c9
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524740B2

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