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Sulfuric Acid → 4-[4-(3-Chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanone

HRID 386595
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HRID 386595 반응식
S(=O)(=O)(O)O.[Cl:6][C:7]1[C:8]([F:37])=[C:9]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:35][CH3:36])=[C:21]([O:24][CH:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)[CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH:10]=[CH:11][CH:12]=1.[OH-].[Na+]>O1CCCC1>[Cl:6][C:7]1[C:8]([F:37])=[C:9]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:35][CH3:36])=[C:21]([O:24][CH:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)[CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH:10]=[CH:11][CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 591581734-[(3-Chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

생성물 1

HCID 581572644-[4-(3-Chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

25 ml of 4M sulphuric acid are added to 9.0 g 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline in 110 ml of tetrahydrofuran and the mixture is stirred for 18 hours at ambient temperature. The mixture is made alkaline with 4M sodium hydroxide solution and extracted several times with ethyl acetate. The combined organic phases are dried, evaporated down and stirred with diethyl ether. The solid is suction filtered and dried.

후처리

  1. extractionextracted several times with ethyl acetate
  2. customThe combined organic phases are dried
  3. customevaporated down
  4. stirringstirred with diethyl ether
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-90d2a74060284b13b9cf32541f09e6c0
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08372855B2

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