4-Hydroxybenzaldehyde → 3-Buten-2-one, 4-(4-hydroxyphenyl)-

HRID 38664

반응식

HRID 38664 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11]([CH3:13])=[O:12]>[OH-].[Na+]>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:10][C:11](=[O:12])[CH3:13])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 1264-HydroxybenzaldehydeHCID 180Acetone

생성물 1

HCID 956483-Buten-2-one, 4-(4-hydroxyphenyl)-수율 70.4%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매2회

실험 절차

4-Hydroxybenzaldehyde (10 g, 82 mmol) was dissolved in 28 ml of 10% sodium hydroxide aqueous solution, then acetone (20 ml) and 10% sodium hydroxide aqueous solution (40 ml) was added under stirring, and the reaction mixture was stirred for 6 hr at room temperature. separated solid diluted with water until all separated solid dissolved. The reaction mixture was neutralized with hydrochloric acid to pH=7.0. The precipitated solid was collected by filtration and washed with water and ethanol successively. The crude product was recrystallized from ethanol to give 9.3 g of a pale yellow solid, mp: 104-105° C., yield: 70.4%.

후처리

  1. stirringthe reaction mixture was stirred for 6 hr at room temperature
  2. customseparated solid
  3. additiondiluted with water until all separated solid
  4. dissolutiondissolved
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water and ethanol successively
  7. customThe crude product was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f526c903b5bf482daf69f8cfb513b16b
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524744B2

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