Lithium Hydroxide → (6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

HRID 38694노트

반응식

HRID 38694 반응식
C([O:3][C:4](=[O:32])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)C.[OH-].[Li+]>O1CCOCC1.O>[CH3:13][O:12][C:9]1[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][O:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[CH:7][C:6]([CH2:5][C:4]([OH:32])=[O:3])=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 67429230(6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester

생성물 1

HCID 45280297(6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
55 °C

실험 절차

To a solution of (6-methoxy-2′-phenoxymethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.24 mmol) in 1,4-dioxane and H2O was added lithium hydroxide (a spatula tip), and the reaction was stirred at 55° C. overnight. After work-up, the crude material was purified by preparative HPLC to give the title compound.

후처리

  1. customAfter work-up, the crude material was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-4ec1fee5261240949706f6ff515f0e8d
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524748B2

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