Phosgene → Carbamic chloride, N-ethyl-N-(phenylmethyl)-

HRID 38696

반응식

HRID 38696 반응식
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].C(N(C(C)C)CC)(C)C.[C:20](Cl)([Cl:22])=[O:21]>C(Cl)Cl>[CH2:4]([N:3]([CH2:1][CH3:2])[C:20]([Cl:22])=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 6371PhosgeneHCID 81531DiisopropylethylamineHCID 84352N-Ethylbenzylamine

생성물 1

HCID 10679448Carbamic chloride, N-ethyl-N-(phenylmethyl)-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (1.9M in toluene; 2.4 mL, 4.6 mmol) was added over 5 minutes, and the reaction was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with diethyl ether (150 mL) and washed twice with H2O. The organic layer was dried and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. additionthe residue was diluted with diethyl ether (150 mL)
  3. washwashed twice with H2O
  4. customThe organic layer was dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ba028587e25a48428392e51037537357
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524748B2

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