Methanol → HCID 57419860, 화합물

HRID 38699

반응식

HRID 38699 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)(Cl)=O.[CH3:17]O>>[CH3:17][O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 34163393-Bromo-4-fluorophenylacetic Acid

생성물 1

HCID 57419860HCID 57419860, 화합물

실험 절차

3-Bromo-4-fluorophenylacetic acid (2.078 g, 8.92 mmol) and thionyl chloride (1.3 mL, 17.84 mmol) were combined in MeOH (20 mL) and stirred at room temperature for 10 minutes. The mixture was concentrated, and the residue was worked up with CH2Cl2 and 1N aqueous NaOH. The organic layer was dried over MgSO4, filtered, and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. dry with materialThe organic layer was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ed4b6c1e36844eacaa4bfe898d5b7ccd
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524748B2

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