Diisopropylethylamine → 1-(4-methoxyphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine

HRID 387006노트

반응식

HRID 387006 반응식
[C:1]1([N:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][C:9]([CH2:18][CH2:19][CH:20]=O)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[CH:26][CH:25]=1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[CH3:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([N:30]2[CH2:35][CH2:34][N:33]([CH2:20][CH2:19][CH2:18][C:9]3[CH:10]=[C:11]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[N:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[N:8]=3)[CH2:32][CH2:31]2)=[CH:28][CH:29]=1

참가 물질

5

반응물 4

HCID 81531DiisopropylethylamineHCID 2697221-(4-Methoxyphenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 426311353-(1,5-diphenyl-1H-pyrazol-3-yl)propanal

생성물 1

HCID 250650501-(4-methoxyphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine

실험 절차

64 mg (93%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (46 mg, 0.166 mmol), 1-(4-methoxyphenyl)piperazine (40 mg, 0.151 mmol), DIPEA (0.026 mL, 0.151 mmol) and NaBH(OAc)3 (96 mg, 0.453 mmol).

후처리

  1. custom64 mg (93%) of target compound was obtained

출처 및 근거

ORD 기록
ord-60fd0ede1058486ba9e43bb6f0c6eb2e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372844B2

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