1-(2-Fluorophenyl)piperazine → HCID 25064648, 화합물

HRID 387090

반응식

HRID 387090 반응식
[C:1]([N:5]1[C:9]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[CH:8][C:7]([CH2:15][CH2:16][CH:17]=O)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[C:1]([N:5]1[C:9]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[CH:8][C:7]([CH2:15][CH2:16][CH2:17][N:29]2[CH2:28][CH2:27][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[F:19])[CH2:31][CH2:30]2)=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 4

HCID 705291-(2-Fluorophenyl)piperazineHCID 81531DiisopropylethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 866399253-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal

생성물 1

HCID 25064648HCID 25064648, 화합물

실험 절차

77 mg (73%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal (50 mg, 0.191 mmol), 1-(2-fluorophenyl)piperazine (34 mg, 0.191 mmol), DIPEA (0.050 mL, 0.287 mmol) and NaBH(OAc)3 (121 mg, 0.573 mmol).

후처리

  1. custom77 mg (73%) of target compound was obtained

출처 및 근거

ORD 기록
ord-5d38d8476fe944d294b67a57dd11a8c8
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372844B2

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