Diisopropylethylamine → 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(4-chlorophenyl)piperazine

HRID 387124

반응식

[C:1]([N:5]1[C:9]([CH2:10][CH2:11][CH:12]=O)=[CH:8][C:7]([CH2:14][CH2:15][CH3:16])=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:20][CH:19]=1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[C:1]([N:5]1[C:9]([CH2:10][CH2:11][CH2:12][N:27]2[CH2:26][CH2:25][N:24]([C:21]3[CH:20]=[CH:19][C:18]([Cl:17])=[CH:23][CH:22]=3)[CH2:29][CH2:28]2)=[CH:8][C:7]([CH2:14][CH2:15][CH3:16])=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 4

HCID 81531Diisopropylethylamine

HCID 974781-(4-Chlorophenyl)piperazine

HCID 5049666Sodium triacetoxyborohydride

HCID 866399303-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal

생성물 1

HCID 685587401-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(4-chlorophenyl)piperazine

실험 절차

171 mg (87%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-(4-chlorophenyl)piperazine (121 mg, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).

후처리

custom171 mg (87%) of target compound was obtained

출처 및 근거

ORD 기록: ord-6dbf59c224a44b8c9d552fd56f5c76f6
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08372844B2

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